Parminder Kaur

Bio

Parminder Kaur is a Research Assistant Professor in Department of Physics at North Carolina State University. She received her M.S. in Physics from State University of New York, Albany and further her PhD from Arizona State University, Tempe under the guidance of Dr. Stuart Lindsay in 2012. Her thesis work was majorly focused on studying epigenetics, specifically DNA methylation, at single molecule level. During her PhD, she also worked as an intern in the pharmaceutical company, Bristol Myers Squibb. After completing her graduate studies at ASU, she joined Dr. Hong Wang’s lab as a postdoctoral researcher became a Research Assistant Professor at North Carolina State University in 2016.

Area(s) of Expertise

Her research focuses on studying protein DNA interactions at single molecule level. She has pioneered aspects of Atomic force Microscopy, particularly those related to live and in air imaging, force spectroscopy and recognition imaging. She has also co-developed a new AFM imaging technique, DREEM (Dual Resonance frequency enhanced EFM), which can visualize DNA in protein DNA complexes at high resolution. Her current work focuses on studying the mitochondrial replication machinery involving twinkle helicase, mitochondrial single stranded DNA binding protein and POLG2, understanding the formation and mechanism involving T-loop at the end of telomeres with shelterin proteins and developing the DREEM imaging technique further.

Publications

• Structure, dynamics, and regulation of TRF1-TIN2-mediated trans- and cis-interactions on telomeric DNA , JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
• TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA , NUCLEIC ACIDS RESEARCH (2021)
• Using Atomic Force Microscopy to Study the Real Time Dynamics of DNA Unwinding by Mitochondrial Twinkle Helicase , BIO-PROTOCOL (2021)
• Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA , NUCLEIC ACIDS RESEARCH (2020)
• DNA looping by two 5-methylcytosine-binding proteins quantified using nanofluidic devices , EPIGENETICS & CHROMATIN (2020)
• Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase , JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
• Cohesin SA2 and EWSR1 in R-Loop Regulation , Biophysical Journal (2019)
• Single-Molecule Study of TRF2 Mediated DNA Compaction using Physiologically Relevant Long Telomeric DNA , Biophysical Journal (2019)
• TIN2 is an Architectural Protein Stabilizing TRF1 at Telomere , Biophysical Journal (2019)
• Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates , Journal of Biological Chemistry (2018)

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