Department of Physics Calendar
CMB Seminar – Christine Payne
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Title: The Underlying Biophysics of Material-Cell Interactions: From TiO2 nanoparticles to conducting polymer wires
Abstract: The goal of the Payne Lab at Duke University is to understand how cells and proteins interact with nanoscale materials and then use this understanding to control cellular properties. This talk will focus on the underlying biophysics that controls these interactions. First, we have recently determined that titanium dioxide nanoparticles, used widely in consumer products, lead to a unique oxidative stress response in human cells. Using a combination of fluorescence microscopy and electron microscopy, we are working to understand how cellular uptake and transport generate this nuclear-level response. Second, we have used nanowires synthesized from PEDOT:PSS to control the action potentials of cardiomyocytes and bacteria, demonstrating the use of a soft bioelectric device for the control of cellular properties. This seminar will discuss the conducting polymer-cell interactions and use of the nanowires for bioelectric studies.