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Christopher Roland

Professor

Partners Building III 120C and Riddick 319C

919-515-3170

Bio

Prof. Roland received his PhD in Physics in 1989 from McGill University, Canada. He then spent a year as a postdoctoral fellow at the University of Toronto, and then at AT&T Bell Laboratories. He joined Physics Department at NC State in 1993 as an Assistant Professor, and has been there ever since. He became an Associate Professor in 1998 and a full Professor in 2002.

Research Description

Prof. Roland’s research interest have been centered primarily in the area of theoretical Condensed Matter Physics and Biophysics. His initial work focused on understanding dynamics and growth phenomena in a variety of materials systems, such as the kinetics of first order phase transitions, homoepitaxy of semiconductors, and the growth of carbon nanotubes. Subsequent research focused on understanding quantum transport in molecular electronic systems for nanoscale applications and development of free energy methods for biomolecular systems. His most recent work is aimed at understanding atypical DNA and RNA structures – particular those associated with Trinucleotide Repeat Expansion Diseases (TREDs) which are behind many severe neurodegenerative and neuromuscular disorders.

Honors and Awards

  • He received an NSF CAREER award in 1995
  • He became a Fellow of the American Physical Society in 2012

Selected Publications

Structure and dynamics of DNA and RNA double helices obtained from the CCG and GGC trinucleotide repeats
F. Pan, V.H. Man, C. Roland and C. Sagui
J. Phys. Chem. B, 122, (2018), 4491

Structural and dynamical characterization of DNA and RNA quadruplexes obtained from GGGGCC and GGGCCT hexanucleotide repeats associated with C9FTD/ALS and SCA36 diseases
Y. Zhang, C. Roland and C. Sagui
ACS Chem. Neuro., 9, (2018), 1104

E-motif formed by extrahelical cytosine bases in DNA homoduplexes of trinucleotide and hexanucleotide repeats
F. Pan, Y. Zhang, V.H. Man, C. Roland and C. Sagui
Nucl. Acids Res., 46, (2017), 942

Comparative melting and healing of B-DNA and Z-DNA by an infrared laser pulse
V.H. Man, F. Pan, C. Sagui and C. Roland
J. Chem. Phys., 144, (2016), 145101

Amyloid properties of asparagine and glutamine in prion-like proteins
Y. Zhang, V.H. Man, C. Roland and C. Sagui
ACS Chem. Neuro., 7, (2016), 576

Ion Distributions Around Left- and Right- handed DNA and RNA duplexes: a comparative study
F. Pan, C. Roland, and C. Sagui
Nucleic Acids Research, 42, (2014), 13981

Investigating Rare Events with Non-equilibrium Work Measurements. II. Transition and Reaction Rates
M. Moradi, C. Sagui, and C. Roland
J. Chem. Phys., 140, (2014), 03415

A Statistical Analysis of the PPII Propensity of Amino Acid Guests in Proline-rich Peptides
M. Moradi, V. Babin, C. Sagui, and C. Roland
Biophysical Journal, 100, (2011), 1083

Dimerization Free Energy of Vancomycin-group Antibiotics and the Cooperative Effect: a Density Functional Approach
J.G. Lee, C. Sagui, and C. Roland
Inter. Journ. Quantum Chem., 110, (2010), 2894

Conformations and Free Energy Landscapes of Polyproline Peptides
M. Moradi, V. Babin, C. Roland, T. Darden, and C. Sagui
Proc. Nat. Acad. Science USA, 106, (2009), 20746

Adaptively Biased Molecular Dynamics for Free Energy Calculations
V. Babin, C. Roland, T. Darden, and C. Sagu
J. Chem. Phys., 128, (2008), 134101

New and exotic self-organized patterns for modulated systems
C. Sagui, E. Asciutto and C. Roland
Nano Lett., 5, (2005), 389